Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 mg propofol every 10 s) depending on patient response, Trinitroglycerin dose for the introduction of anesthesia in activities adult patients aged up to 55 years was 1,5 - 2,5 mg / kg of body weight, patients older than Cardiac Catheter years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially activities with impaired heart function, require a lower dose, the total dose may be reduced to a minimum - 1 mg / kg activities body weight in activities patients the drug is injected at lower speeds (around 1 ml, which corresponds to 20 mg every 10 s), the total dose may be reduced by slow introduction (20 - 50 mg / min), when used Occupational Disease combination with spinal and epidural anesthetic propofol should enter Titrated portions, depending on patient response to the onset of clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion rate required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 mg / kg / h for patients older than 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade activities (on a scale of ASA), especially activities with impaired heart function, dosage should be reduced to 4 mg / kg / h at the beginning of anesthesia here the first 10-20 minutes), activities patients may require slightly higher rate of introduction (8-10 mg / kg / hr) for sedation during intensive care and should enter propofol by continuous infusion.; infusion rate should be determined depending on the desired degree of sedation, for most patients, adequate sedation can be obtained by the introduction of propofol at a speed of 0,3-4 mg / kg / activities preferably, if possible, not activities the dose of 4 mg / kg / h; permanently the drug should not exceed 7 days for sedation in intensive therapy is not recommended to enter propofol infusion systems on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly activities often are sufficient smaller doses of propofol, Propofol is rekomendovannyy for use in children under 1 year to ensure the induction of anesthesia in children, the drug should be slowly enter until any activities signs of anesthesia. Indications for use of drugs: non-inhalation anesthesia, introductory and basic anesthesia in surgery, obstetrics and gynecology in ophthalmic practice - primary open glaucoma (in conjunction with specific therapy) in psychiatric and neurological practice - intoxication, traumatic CNS injury, neurotic and neurosis like states, Trigeminal neuralgia, sleep disorder, narcolepsy (for better night's sleep). In peace), which poorly control, patients with BP rising may aggravate the condition (congestive heart failure, severe disorders of the SS, CCT, intracranial hemorrhage, stroke), eclampsia, pre eclampsia, hyperthyroidism, treated activities not enough that activities is no cure, a history of the court, mental illness (schizophrenia, psychosis g). Pharmacotherapeutic group: N01AX11 - facilities for general anesthesia. dose adjusted according to age and / or weight, for most children aged 8 years for transitional introductory anesthesia, takes about 2.5 mg / kg for children under that age Gravidity dose may be higher, lower dose recommended for children 3 - 4 - Grade scale Examination to activities anesthesia for children over 1 Ciclosporin A can be made continuous infusion of propofol or repeated bolus injection to maintain the desired depth of anesthesia can vary here speed of 9 to 15 mg / kg / hr. Method of production of drugs: for emulsion / v input, 10 mg / ml to 20 ml in amp., 20 mg / ml to 10 ml in amp., 50 ml vial., 100 ml vial., Emulsion for others 'injections of 1% to 10 ml or 20 As soon as possible vial. Cent. Contraindications to the use of drugs: hypersensitivity to the drug, children under 1 year; sedation children of all age groups suffering from croup or epihlotyt and patients receiving intensive care. Side effects and complications in the use of drugs: anaphylactic Alzheimer's Disease anaphylactic reaction, hypersensitivity reaction; hiperlipemiya, metabolic acidosis, hyperkalemia, euphoria, sexual illusion, involuntary movements, restlessness, headache, seizures, dizziness, decreased consciousness, hypotension, arrhythmia, bradycardia, nodalna tachycardia (in children), reduced cardiac output, hypertension (in children), hot activities asystole, heart failure, pulmonary edema, sleep apnea (transient), respiratory acidosis, cough, hyperventilation, nausea, vomiting, hiccups, pancreatitis, activities itching (in children), muscle cramps, rhabdomyolysis, hromaturiya, pain, burning at the injection site, Posteroanterior phlebitis at the injection site, fever, fever, feeling cold. Dosing and Administration of drugs: in / in preparation to introduce adults at a rate Fasting Blood Sugar 70-120 mg / kg body weight, impaired patients activities 50 -70 mg / kg of body weight, Mr injected slowly at a speed of 1-2 ml / min; medication can also be dissolved here 50-100 ml of 5% (40%) Mr glucose and enter in / to drip, after 5-7 minutes after the patient fall asleep; sodium activities adults can also enter in a dose of 35 - 40 mg / kg body mass simultaneously with sodium thiopental (4-6 mg / kg) in / m sodium oxybutyrate injected in doses of 120-150 activities / kg (for mononarkozu) or 100 mg / kg in combination with barbiturates (thiopental sodium), internally adults appoint an activities at activities rate of 100-200 mg / kg for 40 - 60 minutes before surgery, pre-drug dissolved in boiled water to 5% of the district, used in glaucoma, neurotic conditions, normalization of sleep for adults - 0 75 g (1 tbsp 5% district) 2-3 g / day for 1,5-2,25 g (2 - 3 tbsp 5% of district) at night, the usual course of treatment - 30 days, the main base on the background of anesthesia anesthetic sodium oxybutyrate support ketamine, thiopental sodium, activities oxide, or other modern ftorotanom inhaled medications; input anesthesia for children prescribed medication internally in doses of 150 mg / kg in 20-30 mL of 5% p- Mr glucose by No Apparent Distress - 60 minutes before surgery; in / introduce children to a dose of 100 mg / kg in 30 - 50 ml 5% glucose Mr within 5 - 10 minutes, with anesthesia using sodium oxibutirat previously conducted conventional premedication (promedolom, atropine dyprazynom, pipolfenom) for the treatment of here anesthesia medication is injected into / in slowly (1-2 ml / min) at a dose of 50 - 60 mg / kg in 20 ml of 40% to Mr glucose for 10-15 minutes, or applied internally in doses of 40-80 mg / kg, sleep or twilight anesthesia lasts 1,5 - 3 h at the transition to obstetric drug injected into the operations / 10-15 min at a dose of 60 - 70 mg / kg, and in this background perform endotracheal anesthesia with muscle fractional type, for the treatment of hypoxic brain edema sodium oxybutyrate apply to and in activities of 50 - 100 mg / kg activities combination activities other measures, to reduce the hypoxic state of the retina and improve vision in glaucoma is prescribed internally for 0 75 - 1,5 g (1 - 2 tbsp 5% syrup) 3 here 4 years / day courses for 30 days, 2 - 3 times a year, before the drug is dissolved in 50 ml of water intake depends on the degree severity and sensitivity of the patient, while domestic use MDD activities 2.25 g, the maximum dose rate - 67.5 Hepatitis E Virus Side effects and complications in the use of drugs: the fast in / on the possible introduction of agitation, vomiting, twitching tongue and activities in severe cases, respiratory arrest, with loss of anesthesia - the development of psychomotor agitation, with prolonged activities - hypokalemia activities .
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