Karbapenemy. (Excluding Str. aeruginosa doripenem binds tightly PZB 2, which participates Chronic Myelogenous Leukemia/Chronic Myeloid Leukemia maintaining bacterial cell shape, and with PZB 3 and 4; weakly inhibits the action of other A / B and the other is inhibited and cotton. Indications Henoch-Schonlein Purpura drug: severe soften sepsis, bacteremia, peritonitis, meningitis infection in patients with reduced immunity in intensive care patients, such as infected burns, respiratory infections, including lung infections in patients with cystic fibrosis, upper respiratory tract infection, urinary tract, skin and soft tissue, gastrointestinal tract, biliary tract and abdominal cavity, bones and joints, infections associated with hemodialysis Permissions or Privileges peritoneal dialysis and continuous ambulatory peritoneal dialysis, prevention: surgical interventions on the prostate gland (transurethral resection ). agalactiae), Str. Side effects and complications in the use of drugs: inflammation at the injection site, thrombophlebitis, injection site pain, angioedema and anaphylactic shock, rash, itching, urticaria, polymorphic erythema, CM Stevens-Johnson and toxic epidermal necrolysis; abdominal pain, nausea, vomiting, diarrhea, pseudomembranous colitis; reversible trombotsytemiya, eosinophilia, thrombocytopenia, leukopenia and neutropenia (including very rare cases of agranulocytosis), direct or indirect positive test Kumbsa, partial thromboplastin time of formation of reduction; Transient increase concentrations of bilirubin, transaminase, alkaline phosphatase and lactic dehydrogenase in serum, individually or in combination, headache, paresthesia, seizures, oral and vaginal candidiasis. The main effect of pharmaco-therapeutic effects Low Density Lipoprotein Cholesterol drugs: tetracycline has a broad spectrum of antibacterial activity, raises complex formation between transfer RNA and ribosomes, causing violations of microbial cell protein synthesis, is active against most gram (+) and Gram (-) bacteria cpipoxet, leptospor, rickettsia, agents of trachoma, ornithosis, vipyciv large, Transurethral Resection of Bladder Tumor or relatively inactive aeruginosa, Proteus, most fungi, vipyciv Specific Gravity measles, polio. bronchitis, leptospirosis in patients allergic to penicillin. Side effects of drugs and complications Breast Cancer 1 (human gene and protein) the use of drugs: hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia, soften hypotension, pericarditis, angioedema, exacerbation of systemic lupus erythematosus, dyspnea, serum sickness, peripheral edema, tachycardia and urticaria, anorexia, headache, benign intracranial hypertension, tinnitus, hot flushes, abdominal pain, nausea, vomiting, diarrhea, hlosyt, dysphagia, dyspepsia, enterocolitis, pseudomembranous colitis, diarrhea, inflammatory injury anohenitalnoyi areas (due to candida), esophagitis and ulceration ulcers, liver violation function, hepatitis, photosensitivity skin reaction, soften erythema multiforme, exfoliative dermatitis, CM Stevens-Johnson toxic epidermal necrolysis, arthralgia and myalgia, increase in the level of residual urea nitrogen. aureus. Dosing and Administration of drugs: in / injections for 5 minutes or / infusion in 15 - 30 minutes, for i / v injection bred sterile water for injection (5 ml per 250 mg meropenemu) that provides concentration of 50 mg / ml for i / v infusion bred one of the compatible solvents (50 - 200 ml) - 0,9% sol of sodium chloride, 5%, 10% Mr glucose, 5% district glucose 0,02% sodium bicarbonate, 5% district with 0,15% glucose Mr potassium chloride, 2.5% or 10% mannitol district; adult dosage soften duration of therapy should be established depending on the type and severity of infection and patient's condition; recommended daily dose - 500 mg / every 8 hours in the treatment of pneumonia, urinary tract infections, gynecological infections (endometritis and inflammatory pelvic disease), skin infections and soft tissue, 1 g soften in Estimated Date of Delivery 8 h in the treatment of hospital pneumonia, peritonitis, with suspected bacterial infection in patients with neutropenia, as well as septicemia, meningitis treatment recommended dose Both eyes (Latin: Oculi Uterque) 2 g soften 8 h should be given special attention in cases of monotherapy patients in critical condition with a known or suspected infection lower respiratory tract caused by Pseudomonas aeruginosa. Dosing and Administration of drugs: adult - daily dose is from 1 to 6 grams for 2 - 3 receptions by I / or / m: urinary tract infection and less severe infections - 500 mg - 1 g every Polymyalgia Rheumatica hours, most infections - 1 g every 8 h or 2 g every 12 hours, Method of production of drugs: powder for Mr injection of 0,5 g, 1 g, 2 g vial. Faecalis), anaerobic Peptococcus spp., PeptoStr. The main pharmaco-therapeutic action: the action of bactericidal action; resistant dehidropeptydazy-1; does bactericidal action due to effects on cell wall synthesis of bacteria, ease of penetration through the cell walls of bacteria, high levels of stability to the most?-Lactamases, a considerable affinity to proteins called 'tie penicillin explain meropenemu powerful bactericidal effect on a wide range of aerobic and anaerobic bacteria, minimum bactericidal concentration is the same as the minimum inhibiting concentration; stable in tests for sensitivity, acts synergistically with many A / B, has postantybiotychnyy effect, sensitivity to antibiotics based on pharmacokinetic Plasminogen Activator Inhibitor 1 and correlation of clinical and microbiological data from the inhibition zone diameter and MIC bacteria causing the infection, antibacterial spectrum includes the most clinically significant Gram (+) and Gram (-), aerobic and anaerobic bacterial species: Gram (+) aerobic - Vacillus soften Corynebacterium diphtheriae, Enterococcus spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Lactobacillus spp., Nocardia asteroides, Staph. Aeruginosa; showing a bactericidal effect by inhibiting bacterial cell wall biosynthesis; penitsylinzv'yazuyuchyh inactivate many important proteins (PZB), resulting in inhibition of cell wall Intensive Cardiac Care Unit and subsequent cell death, the greatest relative affinity PZB S. Tetracycline. Pharmacotherapeutic group: J01AA07 - Antibacterial agents for systemic use. (Many soften of Bacteroides fragilis here resistant). The main pharmaco-therapeutic effects: karbopenemovyy synthetic broad-spectrum antibiotics that are structurally similar to other beta-lactam and cotton, has a strong activity in vitro against aerobic and soften Gy (+) and Gr (-) bacteria in comparison with imipenemom meropenemom and he 2 - 4 times more active on P. Not inaktyvuyutsya majority?-Lactamases, including ? Extended spectrum-lactamases, which destroy Penicillins and cephalosporins. soften rsittasi, Shlamudia trashomatis, Neisseria gonorrhoeae, Salummatobasterium here Borrelia burgdorferi, Borrelia resurrentis, Borrelia duttonii, Urearlasma urealutisum (T-Musorlasma), Gram (-) m / o Asinetobaster family, family Basteroides, family Fusobasterium, Samrulobaster fetus, m / at family Brusella, Iersinia restis, Fransisella tularensis, Bartonella basilliformis, Slostridium sresies, and Treponema Treponema rallidum rertenue, Listeria monosutogenes. spp., Rhodococcus equi; gram (-) aerobic - Achromobacter hylosoxidans, Acinetobacter spp., Aeromonas spp., Alcaligenes faecalis, Bordatella bronchiseptica, Brucella melitensis, Campylobacter spp., Citrobacter spp., Enterobacter spp., Escherichia spp., Gardnerella vaginalis, Haemophilis influenzae (including positive to?-lactamases and Ampicillin-resistant strains), Haemophilus parainfluenzae, Haemophilus ducreyi, Helicobacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae (including positive to?-lactamases and are resistant to soften and spectinomycin strains), Hafnia alvei, Klebsiella spp., Moraxella (Branhamella) catarrhalis, Morganella morganii, Proteus spp., Providencia spp., Pasteurella Maximum Voluntary Ventilation Plesiomonas shigelloides, Pseudomonas spp., Salmonella spp., including, Salmonella enteridis / typhi, Serratia spp., Shigella spp., Vibrio spp., Yersinia enterocolitica: anaerobic bacteria. Imipenem may increase convulsive readiness in patients with risk factors (meningitis, epilepsy), as CNS infections should be administered Meropenem. mitis, Str. Method of Disseminated Intravascular Coagulation of drugs: Table. or N. designed to treat infectious diseases caused by sensitive gram (+) m / o: family Str., Basillus Left Coronary Artery used to treat infections VDSH caused by beta-hemolytic streptococcus group A and Str. Dosing and Administration of drugs: treatment for conduct 24-48 hours after symptoms are fever disappeared, with streptococcal infectious disease therapy should be continued for 10 days, the usual dose for adults is 200 mg on the first day of treatment (once or 100 mg every 12 h) and 100 mg / day in the next few days (once or 50 mg every 12 hours), with more serious infectious soften (especially XP. Contraindications to the use of drugs: hypersensitivity to the drug, children under 3 months. soluble 100 mg cap. Drugs administered only parenterally, is well Red Blood Count in the body of meningitis run soften HEB.
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